Research Interests:

Bringing proteome-level analysis (prediction, analysis and validation of protein structural and functional features, activities, and interactions) to the massive amount of genome data now being generated in organisms ranging from microbes to human. My research areas have included:

• development and applications of high-resolution modeling of protein and peptides
• predicting protein stability and binding specificity
• antigen presentation complexes
• algorithms and systems for genome analysis and functional identification
• structural approaches to solving sequence alignment problems: detecting & aligning distant homologies